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Respuesta inmune producida por plaquetas durante la infección con Mycobacterium tuberculosis

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dc.contributor Bruno Rivas-Santiago;0000-0002-1521-1519 es_MX
dc.contributor Esther Layseca-Espinosa;0000-0002-2824-5486 es_MX
dc.contributor.advisor Rivas Santiago, Bruno
dc.contributor.advisor Layseca Espinosa, Esther
dc.contributor.author Torres Juárez, Flor de María
dc.coverage.spatial Zacatecas. Zacatecas. México es_MX
dc.creator FLOR DE MARIA TORRES JUAREZ;614497 es_MX
dc.date.accessioned 2022-08-31T16:24:23Z
dc.date.available 2022-08-31T16:24:23Z
dc.date.issued 2020-10
dc.identifier.uri https://repositorioinstitucional.uaslp.mx/xmlui/handle/i/7930
dc.identifier.uri https://doi.org/10.1016/j.micpath.2021.104768 en
dc.description.abstract Tuberculosis (TB) is the first cause of death by a single infectious agent. Previous reports have highlighted the presence of platelets within Tb granulomas, albeit the immune-associated platelet response to Mycobacterium tuberculosis (Mtb) has not be deeply studied. Our results showed that platelets are recruited into the granuloma in the late stages of tuberculosis. Furthermore, electron-microscopy studies showed that platelets can internalize Mtb and produce host defense peptides (HDPs), such as RNase 7, HBD2 and hPF-4 that bind to the internalized Mtb. Mtb-infected platelets exhibited higher transcription and secretion of IL-1ß and TNF-α, whereas IL-10 and IL-6 protein levels decreased. These results suggest that platelets participate in the immune response against Mtb through HDPs and cytokines production. es_MX
dc.description.sponsorship CONACYT, Beca 614497 es_MX
dc.description.sponsorship Proyecto R-2015-785-075, Financiamiento FIS/IMSS/PROT/PRIO/16/051, IMSS es_MX
dc.description.statementofresponsibility Investigadores es_MX
dc.description.statementofresponsibility Estudiantes es_MX
dc.language Inglés es_MX
dc.relation.ispartof REPOSITORIO NACIONAL CONACYT es_MX
dc.relation.requires RNase 7 but not psoriasin nor sPLA2-IIA associates with Mycobacterium tuberculosis during airway epithelial cell infection, 2018, Research article es_MX
dc.relation.requires Host Defense Peptide RNase 7 Is Down-regulated in the Skin of Diabetic Patients with or without Chronic Ulcers, and its Expression is Altered with Metformin, 2020, Research article es_MX
dc.relation.requires Nicotine modulates molecules of the innate immune response in epithelial cells and macrophages during infection with M. tuberculosis, 2019, Research article es_MX
dc.relation.requires Antimicrobial Peptides-based Nanostructured Delivery Systems: An Approach for Leishmaniasis Treatment, 2019. Review article es_MX
dc.relation.requires Antimicrobial peptides for the treatment of pulmonary tuberculosis, allies or foes?, 2018. Review article es_MX
dc.relation.requires lysX gene is differentially expressed among Mycobacterium tuberculosis strains with different levels of virulence, 2017. Research article es_MX
dc.relation.requires Differences in Cytokine Production during Aging and Its Relationship with Antimicrobial Peptides Production, Review article es_MX
dc.relation.requires Glucose levels affect LL-37 expression in monocyte-derived macrophages altering the Mycobacterium tuberculosis intracellular growth control, 2016, Research article es_MX
dc.relation.uri https://doi.org/10.1093/femspd/fty054 es_MX
dc.relation.uri https://doi.org/10.1016/j.arcmed.2020.03.006 es_MX
dc.relation.uri https://doi.org/10.1111/cei.13388 es_MX
dc.relation.uri https://doi.org/10.2174/1381612825666190628152842 es_MX
dc.relation.uri https://doi.org/10.2174/1381612824666180327162357 es_MX
dc.relation.uri http://dx.doi.org/10.1016/j.tube.2017.07.005 es_MX
dc.relation.uri http://dx.doi.org/10.1080/08820139.2016.1212873 es_MX
dc.relation.uri http://dx.doi.org/10.1016/j.micpath.2016.06.002 es_MX
dc.rights Acceso Abierto es_MX
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0 es_MX
dc.subject Tuberculosis es_MX
dc.subject platelets es_MX
dc.subject immune response es_MX
dc.subject host defense peptides es_MX
dc.subject.other BIOLOGÍA Y QUIMICA es_MX
dc.subject.other MEDICINA Y CIENCIAS DE LA SALUD es_MX
dc.title Respuesta inmune producida por plaquetas durante la infección con Mycobacterium tuberculosis es_MX
dc.title.alternative Platelets immune response against Mycobacterium tuberculosis infection en
dc.type Tesis de doctorado es_MX
dc.degree.name Doctorado en Ciencias Biomédicas Básicas es_MX
dc.degree.department Facultad de Medicina es_MX


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