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Caracterización ultraestructural de la infección in vitro del virus sincicial respiratorio

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dc.contributor MAURICIO COMAS GARCIA;221633 es_MX
dc.contributor ANDREU COMAS GARCIA;302961 es_MX
dc.contributor SOFIA BERNAL SILVA;165702 es_MX
dc.contributor ROSA MARIA WONG CHEW;121599 es_MX
dc.contributor.advisor Comas García, Mauricio es_MX
dc.contributor.advisor Comas García, Andreu es_MX
dc.contributor.advisor Bernal Silva, Sofía es_MX
dc.contributor.advisor Noyola Cherpitel, Daniel Ernesto es_MX
dc.contributor.advisor Wong Chew, Rosa María es_MX
dc.contributor.author Lara Hernández, Ignacio es_MX
dc.coverage.spatial México. San Luis Potosí. San Luis Potosí es_MX
dc.creator Ignacio Lara Hernández;0009-0009-2053-5671 es_MX
dc.date.accessioned 2023-08-17T18:51:11Z
dc.date.available 2023-08-17T18:51:11Z
dc.date.issued 2023-08-16
dc.identifier.uri https://repositorioinstitucional.uaslp.mx/xmlui/handle/i/8350
dc.description.abstract Human respiratory syncytial virus (hRSV) is the leading cause of acute lower respiratory tract infections in children under five years of age and older adults worldwide. During hRSV infection, host cells undergo changes in endomembrane organelles, including mitochondria. This organelle is responsible for energy production in the cell and plays an important role in the antiviral response. The present study focuses on characterizing the ultrastructural and functional changes during hRSV infection using thin-section transmission electron microscopy and RT-qPCR. Here we report that hRSV infection alters mitochondrial morphodynamics by regulating the expression of key genes in the antiviral response process, such as Mfn1, VDAC2, and PINK1. Our results suggest that hRSV alters mitochondrial morphology during infection, producing a mitochondrial phenotype with shortened cristae, swollen matrix, and damaged membrane. We also observed that hRSV infection modulates the expression of the aforementioned genes, possibly as an evasion mechanism in the face of cellular antiviral response. Taken together, these results advance our knowledge of the ultrastructural alterations associated with hRSV infection and might guide future therapeutic efforts to develop effective antiviral drugs for hRSV treatment. es_MX
dc.description.statementofresponsibility Investigadores es_MX
dc.description.statementofresponsibility Estudiantes es_MX
dc.language Inglés es_MX
dc.publisher Facultad de Medicina es_MX
dc.rights Acceso Abierto es_MX
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0 es_MX
dc.subject Human respiratory syncytial virus es_MX
dc.subject Mitochondrial alterations es_MX
dc.subject Ultrastructural characterization es_MX
dc.subject Virus sincitial respiratorio humano (bvs) es_MX
dc.subject Mitocondrias (bvs) es_MX
dc.title Caracterización ultraestructural de la infección in vitro del virus sincicial respiratorio es_MX
dc.type Tesis de doctorado es_MX
dc.degree.name Doctorado en Ciencias Biomédicas Básicas es_MX
dc.degree.department Facultad de Medicina es_MX

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