Papel del sistema purinérgico en cambios conductuales y patológicos en un modelo farmacológico de esquizofrenia

Abstract

Ketamine hydrochloride serves multiple purposes, including its use as a general anesthetic, treatment for depression, and recreational drug. In studies involving rodents, ketamine is utilized as a model for schizophrenia. However, it is unclear whether age affects the behavioral response induced by repeated ketamine administration and if it modifies the expression levels of N-methyl-D-aspartate (NMDA) and a-amino-3-hydroxy-5-methyl-4-isoxazoleproplonic acid (AMPA) and purinergic receptors (P2X1, P2X4, P2X7). In the present study, we evaluated the effect of intraperitoneal administration of subanesthetic ketamine dose (30mg/Kg) for fourteen days on Young (35 days of age) and adult (76 days of age) mice on diferentt behavioral tests.